An antidiabetic phospholipid

an antidiabetic compound from vaccinium arctostaphylos berries

Antidiabetic Actions of an Estrogen Receptor β Selective Agonist

The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY...

Safe Oral Antidiabetic Agents in Cardiac Patients: An Update

Cardiovascular disease is the major cause of mortality among patients with type 2 diabetes mellitus, accounting for 60-80% of death in these patients. Despite recent studies demonstrating likely benefit of good glycaemic control in decreasing cardiovascular risk in type 2 DM, there have been lingering concerns about potential adverse cardiovascular effects of insulin secretagogues, specifically...

Acute and subacute toxicity of an antidiabetic Siddha herbal formulation

The management of diabetes is considered a global problem. FS002, a polyherbal Siddha formulation intended to be used for diabetic patients, has been screened for toxic effect. For sub-acute toxicity studies, different doses of FS002 were administered orally to rats once daily for 30 days. Animals were observed for physiological and behavioral responses, mortality, food, water intake and body w...

Floating Drug Delivery of Antidiabetic Drugs: an Overview

Despite the tremendous advancement in drug delivery, oral route remains the preferred route for the administration due to higher levels of patient compliance. But conventional forms offer no control over drug delivery, leading to fluctuations in plasma drug level. These have a disadvantage of a release all or nothing emptying process while the multiple unit particulate system pass through the g...